Spinal and supraspinal opioid analgesia in the mouse: the role of subpopulations of opioid binding sites
1983; Elsevier BV; Volume: 271; Issue: 1 Linguagem: Inglês
10.1016/0006-8993(83)91376-8
ISSN1872-6240
AutoresGeoffrey Ling, Gavril W. Pasternak,
Tópico(s)Pain Mechanisms and Treatments
ResumoThe selective in vivo blockade of high affinity (mu1) opioid binding sites in mice by naloxazone reduced the analgesic potency of opiates and opioid peptides, evidenced by a shift of their analgesic ED50 values. However, the extent of these shifts varied significantly between a series of opioid drugs, ranging from 12-fold for morphine to 4-fold ford-Ala2-d-Leu5-enkephalin. These findings suggested that analgesia in naloxazone-treated animals is mediated through a different subpopulation of receptors than in normal controls. Correlating these analgesic shifts for a series of opioids with their affinity for different [3H]opioid binding sites suggested an analgesic role for delta sites. Additional studies in mice with spinal transections suggested that mu1 analgesia was primarily supraspinal.
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