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Association between ischemia-modified albumin, lipids and inflammation biomarkers in patients with hypercholesterolemia

2009; Elsevier BV; Volume: 42; Issue: 7-8 Linguagem: Inglês

10.1016/j.clinbiochem.2009.01.010

1873-2933

Marta Maria Medeiros Frescura Duarte, João Batista Teixeira da Rocha, Rafael Noal Moresco, Thiago Duarte, Ivana Beatrice Mânica da Cruz, Vânia Lúcia Loro, Maria Rosa Chitolina Schetinger,

Adipokines, Inflammation, and Metabolic Diseases

The aim of this study was to evaluate the association between ischemia-modified albumin (IMA), lipids and inflammation biomarkers in patients with hypercholesterolemia, and the possible involvement of IMA in atheromatous plaque development and oxidative stress.Glucose, total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides, oxidized LDL (ox-LDL), ox-LDL autoantibodies, high-sensitivity C reactive protein (hs-CRP), and IMA were measured in 37 subjects with hypercholesterolemia and 37 controls.Total cholesterol, LDL cholesterol, triglycerides, ox-LDL, ox-LDL autoantibodies, hs-CRP, and IMA were higher in the hypercholesterolemia group, and HDL cholesterol levels were lower in this group. We observed significant correlations between IMA and total cholesterol, LDL cholesterol, ox-LDL antibodies, and hs-CRP levels. Significant correlations were also observed between hs-CRP and total cholesterol, HDL cholesterol, LDL cholesterol, ox-LDL, ox-LDL autoantibodies, and triglycerides.Hypercholesterolemia is associated with an increase in inflammatory and oxidative stress biomarkers, and it also reduces the capacity of albumin to bind cobalt owing to ischemia, resulting in an increased IMA. IMA formation appears to be associated with oxidative stress and atheromatous plaque development.