A Novel Transurethral Microwave Thermal Ablation System to Treat Benign Prostatic Hyperplasia: Results of a Prospective Multicenter Clinical Trial
1997; Lippincott Williams & Wilkins; Volume: 158; Issue: 1 Linguagem: Inglês
10.1097/00005392-199707000-00032
ISSN1527-3792
AutoresErnest W. Ramsey, Paul D. Miller, Keith Parsons,
Tópico(s)Kidney Stones and Urolithiasis Treatments
ResumoNo AccessJournal of UrologyClinical Urology: Original Article1 Jul 1997A Novel Transurethral Microwave Thermal Ablation System to Treat Benign Prostatic Hyperplasia: Results of a Prospective Multicenter Clinical Trial Ernest W. Ramsey, Paul D. Miller, and Keith Parsons Ernest W. RamseyErnest W. Ramsey , Paul D. MillerPaul D. Miller , and Keith ParsonsKeith Parsons View All Author Informationhttps://doi.org/10.1097/00005392-199707000-00032AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We evaluated the efficacy, safety and impact on quality of life of a newly designed microwave thermal ablation system in patients with benign prostatic hyperplasia (BPH). Materials and Methods: Microwave thermal ablation was administered to 154 BPH patients at 3 centers in Canada and the United Kingdom during a single 1 to 2-hour office or clinic procedure without general or regional anesthesia and without need for potent medications necessitating intensive patient monitoring. Various measures of symptoms, voiding function and patient quality of life were assessed at baseline, 6 weeks, and 3, 6, 9 and 12 months after treatment. Results: Mean American Urological Association symptom score 12 months after treatment (8.8, 95% confidence interval 7.7 to 10.0) was significantly lower (p <0.05) by 56% than that at baseline (20.1, 95% confidence interval 19.1 to 21.0). The incidence of mild symptoms increased from 0 to 57%, while that of severe symptoms decreased from 49 to 8%. There was a significant increase (p <0.05) in peak flow rate of 45% from 9.3 ml. per second (95% confidence interval 8.8 to 9.7) at baseline to 13.4 ml. per second (95% confidence interval 12.5 to 14.4) at 12 months. Similar symptomatic and urodynamic improvements occurred in all prostate volume categories. Convalescence was rapid after treatment with little or no need for home bed rest or restriction of usual activities. Patients expressed a high level of satisfaction with treatment and found the prostate symptoms to be significantly more tolerable. Adverse events were infrequent, transient and readily managed. Conclusions: Microwave thermal ablation proved to be safe and effective for treatment of BPH with a significant positive impact on patient quality of life. References 1 : The development of human benign prostatic hyperplasia with age.. J. Urol.1984; 132: 474. Link, Google Scholar 2 : High prevalence of benign prostatic hypertrophy in the community.. Lancet1991; 338: 469. 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Abstract, Google Scholar From the Department of Urology, University of Manitoba Health Sciences Centre, Winnipeg, Manitoba, Canada, and East Surrey Hospital, East Surrey and Royal Liverpool University Hospital, Liverpool, United Kingdom.© 1997 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byFLORATOS D, KIEMENEY L, ROSSI C, KORTMANN B, DEBRUYNE F and de la ROSETTE J (2018) LONG-TERM FOLLOWUP OF RANDOMIZED TRANSURETHRAL MICROWAVE THERMOTHERAPY VERSUS TRANSURETHRAL PROSTATIC RESECTION STUDYJournal of Urology, VOL. 165, NO. 5, (1533-1538), Online publication date: 1-May-2001.DJAVAN B, ROEHRBORN C, SHARIAT S, GHAWIDEL K and MARBERGER M (2018) PROSPECTIVE RANDOMIZED COMPARISON OF HIGH ENERGY TRANSURETHRAL MICROWAVE THERMOTHERAPY VERSUS alpha-BLOCKER TREATMENT OF PATIENTS WITH BENIGN PROSTATIC HYPERPLASIAJournal of Urology, VOL. 161, NO. 1, (139-143), Online publication date: 1-Jan-1999.DJAVAN B, FAKHARI M, SHARIAT S, GHAWIDEL K and MARBERGER M (2018) A NOVEL INTRAURETHRAL PROSTATIC BRIDGE CATHETER FOR PREVENTION OF TEMPORARY PROSTATIC OBSTRUCTION FOLLOWING HIGH ENERGY TRANSURETHRAL MICROWAVE THERMOTHERAPY IN PATIENTS WITH BENIGN PROSTATIC HYPERPLASIAJournal of Urology, VOL. 161, NO. 1, (144-151), Online publication date: 1-Jan-1999.DJAVAN B, SHARIAT S, SCHAFER B and MARBERGER M (2018) TOLERABILITY OF HIGH ENERGY TRANSURETHRAL MICROWAVE THERMOTHERAPY WITH TOPICAL URETHRAL ANESTHESIA: RESULTS OF A PROSPECTIVE, RANDOMIZED, SINGLE-BLINDED CLINICAL TRIALJournal of Urology, VOL. 160, NO. 3 Part 1, (772-776), Online publication date: 1-Sep-1998.Larson T, Collins J and Corica A (2018) DETAILED INTERSTITIAL TEMPERATURE MAPPING DURING TREATMENT WITH A NOVEL TRANSURETHRAL MICROWAVE THERMOABLATION SYSTEM IN PATIENTS WITH BENIGN PROSTATIC HYPERPLASIAJournal of Urology, VOL. 159, NO. 1, (258-264), Online publication date: 1-Jan-1998. Volume 158Issue 1July 1997Page: 112-119 Advertisement Copyright & Permissions© 1997 by American Urological Association, Inc.MetricsAuthor Information Ernest W. Ramsey More articles by this author Paul D. Miller More articles by this author Keith Parsons More articles by this author Expand All Advertisement PDF downloadLoading ...
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