Prophylaxis against Pneumocystis carinii pneumonia for HIV-exposed infants in Africa
2002; Elsevier BV; Volume: 360; Issue: 9349 Linguagem: Inglês
10.1016/s0140-6736(02)11921-0
ISSN1474-547X
Autores Tópico(s)HIV/AIDS drug development and treatment
ResumoMore than 90% of childhood HIV infection now occurs in sub-Saharan Africa, and most is attributable to mother-to-child transmission. Data from the region show that Pneumocystis carinii pneumonia (PCP) is a common cause of severe pneumonia and death in HIV-infected infants. Co-trimoxazole prophylaxis (5 parts sulfamethoxazole and 1 part trimethroprim) is highly effective in the prevention of PCP, and is readily available in resource-poor regions. However, PCP prophylaxis is rarely provided for African infants even in the research context of HIV mother-to-child transmission studies, in which HIV-exposed children are identified and actively followed up.
Referência(s)