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Evaluation of the neuroprotective activity of stansin 6, a resin glycoside from Ipomoea stans

2014; Elsevier BV; Volume: 24; Issue: 15 Linguagem: Inglês

10.1016/j.bmcl.2014.05.055

1464-3405

Ismael León‐Rivera, Juana Villeda‐Hernández, Victoria Campos‐Peña, Alma Aguirre-Moreno, Samuel Estrada‐Soto, Gabriel Navarrete‐Vázquez, Marı́a Yolanda Rios, A. Berenice Aguilar‐Guadarrama, Patricia Castillo-España, Julio César Rivera‐Leyva,

Neuroinflammation and Neurodegeneration Mechanisms

Stansin 6 a tetrasaccharide resin glycoside isolated from the root of Ipomoea stans was evaluated as anticonvulsant and neuroprotective in kainic acid-induced seizures of rats. Intraperitoneal injection of kainic acid (10 mg/kg) induced typical behavioral seizures such as wet dog shakes and limbic seizures, and histopathological changes in the hippocampus (degeneration and loss of pyramidal cells in CA1 to CA4 areas). Stansin 6 (10–80 mg/kg) had no effect on the behavior of rats and did not induce hippocampal damage. Pretreatment with stansin 6 inhibited convulsions in rats from kainic acid-induced seizures, reduced the degeneration pattern in the CA3 region, decreased astrocytic reactivity, and reduced the expression of IL-1β and TNF-α induced by kainic acid. These results suggest that stansin 6 possesses neuroprotective and anticonvulsant activities.