Comparison of human polymorphonuclear neutrophil elastase, polymorphonuclear neutrophil cathepsin-G, and α2-macroglobulin levels in healthy and inflamed dental pulps
1994; Elsevier BV; Volume: 20; Issue: 11 Linguagem: Inglês
10.1016/s0099-2399(06)80070-1
ISSN1878-3554
AutoresCindy R. Rauschenberger, Scott B. McClanahan, Ernest D. Pederson, Donald W. Turner, E. Kaminśki,
Tópico(s)Protease and Inhibitor Mechanisms
ResumoPolymorphonuclear neutrophils (PMNs) are found in dental pulp secondary to carious exposures, periodontal disease, or trauma. Lysosomal degranulation of these cells liberates cellular proteases, including elastase (PMN-E) and cathepsin-G (PMN-CG), which produce connective tissue degradation. However, nonspecific pulpal tissue destruction can be modified by a naturally occurring serum protease inhibitor α 2 -macroglobulin (A 2 -M). This study relates the concentrations of human PMN-E, PMN-CG, and A 2 -M in healthy and inflamed pulpal samples. Evaluation of 21 specimens yielded statistically significant differences between healthy and moderate to severely inflamed pulps for all groups (p < 0.05). No significant correlation was detected among human PMN-E, PMN-CG, and A 2 -M in the healthy tissues (p > 0.05). However, in the moderate to severely inflamed pulps, there was a significant correlation between PMN-CG and A 2 -M (p < 0.05).
Referência(s)