The Central Nervous System as a Sanctuary Site in ALK-Positive Non–Small-Cell Lung Cancer
2013; Elsevier BV; Volume: 8; Issue: 12 Linguagem: Inglês
10.1097/jto.0000000000000029
ISSN1556-1380
AutoresJustin F. Gainor, Sai‐Hong Ignatius Ou, Jennifer Logan, Lawrence F. Borges, Alice T. Shaw,
Tópico(s)Lung Cancer Diagnosis and Treatment
ResumoAnaplastic lymphoma kinase ( ALK ) gene rearrangements define a distinct molecular subset of non–small-cell lung cancer that is highly responsive to treatment with the ALK inhibitor crizotinib. Recently, it has been recognized that the brain is a frequent site of relapse among ALK-positive patients treated with crizotinib. In this report, we expand on these observations and present a series of ALK-positive patients with two distinct forms of metastatic, central nervous system involvement: intramedullary spinal cord metastasis and leptomeningeal carcinomatosis.
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