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IL10 inversely correlates with the percentage of CD8+ cells in MDS patients

2013; Elsevier BV; Volume: 37; Issue: 5 Linguagem: Inglês

10.1016/j.leukres.2013.01.019

1873-5835

Matheus Rodrigues Lopes, Fabı́ola Traina, Paula de Melo Campos, João Kleber Novais Pereira, João Agostinho Machado‐Neto, Helymar da Costa Machado, Simone Cristina Olenscki Gilli, Sara Teresinha Olalla Saad, Patrícia Favaro,

T-cell and B-cell Immunology

The role of the immune system in myelodysplastic syndrome (MDS) progression has been widely accepted, although mechanisms underlying this immune dysfunction are not clear. CD4+ and CD8+ lymphocyte profiles in the peripheral blood of MDS patients were evaluated and correlated with clinical characteristics, the expression of FOXP3 and the anti-inflammatory cytokines IL10, TGFβ1 and CTLA4. IL10 expression inversely correlated with the percentage of CD8+ cells and was higher in high-risk MDS. Our findings provide further evidence for the role of T cell-mediated IL10 production in MDS and strengthen the idea of distinct cytokine profiles in low and high-risk MDS.