Significance of Serum Free Prostate Specific Antigen in the Screening of Prostate Cancer
1996; Lippincott Williams & Wilkins; Volume: 156; Issue: 6 Linguagem: Inglês
10.1016/s0022-5347(01)65405-3
ISSN1527-3792
AutoresEiji Higashihara, Kikuo Nutahara, Miho Kojima, Takatsugu Okegawa, Ichiro Miura, Akiomi Miyata, Moriaki Kato, Hajime Sugisaki, Takeshi Tomaru,
Tópico(s)Urologic and reproductive health conditions
ResumoNo AccessJournal of UrologyClinical Urology: Original Article1 Dec 1996Significance of Serum Free Prostate Specific Antigen in the Screening of Prostate Cancer Eiji Higashihara, Kikuo Nutahara, Miho Kojima, Takatsugu Okegawa, Ichiro Miura, Akiomi Miyata, Moriaki Kato, Hajime Sugisaki, and Takeshi Tomaru Eiji HigashiharaEiji Higashihara , Kikuo NutaharaKikuo Nutahara , Miho KojimaMiho Kojima , Takatsugu OkegawaTakatsugu Okegawa , Ichiro MiuraIchiro Miura , Akiomi MiyataAkiomi Miyata , Moriaki KatoMoriaki Kato , Hajime SugisakiHajime Sugisaki , and Takeshi TomaruTakeshi Tomaru View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)65405-3AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: The significance of serum free prostate specific antigen (PSA) in the screening of prostate cancer was examined. Materials and Methods: A prospective clinical trial was conducted on 701 male volunteers 50 years old or older. Serum free PSA was determined and biopsies were performed if PSA was greater than 4 ng./ml. or if digital rectal examination was suspicious for cancer. Results: Of the men 187 (27 percent) had a PSA of greater than 4 ng./ml. (11 percent) and/or a suspicious digital rectal examination (19 percent). Of 116 biopsies performed in the 701 men cancer was detected in 13 (1.9 percent). PSA detected more tumors (12 of 13, 92 percent) than digital rectal examination (9, 69 percent). Receiver operating characteristic analysis showed that the optimal free PSA-to-PSA ratio (free PSA ratio) was 12 percent. The positive predictive value for cancer according to PSA with free PSA ratio (50 percent, 10 cancers in 20 biopsies) was significantly greater (p = 0.0473) than that according to PSA alone (24 percent, 12 cancers in 50 biopsies), which indicated that 30 of 50 biopsies were avoided with only 2 cancers missed when PSA and free PSA were used for biopsy indication. Conclusions: Free PSA determination might eliminate unnecessary biopsies in men with a PSA of more than 4 ng./ml. with minimal missed cancers. References 1 : Cancer statistics, 1995.. Ca1995; 45: 8. Google Scholar 2 : Cancer in the European community and its member states.. Eur. J. Cancer1990; 26: 1167. Google Scholar 3 : Cancer statistics, incidence, death and prognosis--1993. Tokyo: Shinohara-Shuppan1993. Google Scholar 4 : studies on endocrine therapy for prostatic carcinoma (2): prognosis of patients with prostatic carcinoma given endocrine therapy, and analyses on causes of death and side effect of endocrine therapy.. 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Abstract, Google Scholar Department of Urology, Kyorin University, School of Medicine, Mitaka, and SRL Incorporated, Tachikawa, Tokyo, Japan.© 1996 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byScovell J, Hettel D, Abouassaly R, Almassi N, Berglund R, Breaux T, Weight C, Isac W, Zampini A, Stark E, Rochelle R, Kestranek A, Stovsky M and Klein E (2021) IsoPSA® Reduces Provider Recommendations for Biopsy and Magnetic Resonance Imaging in Men with Total Prostate Specific Antigen ≥4 ng/ml: A Real-World Observational Clinical Utility StudyUrology Practice, VOL. 9, NO. 2, (173-180), Online publication date: 1-Mar-2022.Stovsky M, Klein E, Chait A, Manickam K, Stephenson A, Wagner M, Dineen M, Lotan Y, Partin A, Baniel J, Kestranek A, Gawande P and Boris Zaslavsky (2019) Clinical Validation of IsoPSA™, a Single Parameter, Structure Based Assay for Improved Detection of High Grade Prostate CancerJournal of Urology, VOL. 201, NO. 6, (1115-1120), Online publication date: 1-Jun-2019.KOBAYASHI T, KAMATO T, ISOGAWA Y, KINOSHITA H, TERAI A, HABUCHI T and OGAWA O (2018) Ratio Of Prostate Specific Antigen Minor Molecular Forms-To-Total Prostate Specific Antigen Is Constant Regardless Of The Pathological Condition Of The ProstateJournal of Urology, VOL. 169, NO. 1, (121-124), Online publication date: 1-Jan-2003.Williams P, Eastham J, Culkin D, Mata J, Venable D and Sartor O (2018) INFLUENCE OF HEPATIC FUNCTION ON SERUM LEVELS OF PROSTATE SPECIFIC ANTIGENJournal of Urology, VOL. 158, NO. 5, (1867-1869), Online publication date: 1-Nov-1997. Volume 156Issue 6December 1996Page: 1964-1968 Advertisement Copyright & Permissions© 1996 by American Urological Association, Inc.MetricsAuthor Information Eiji Higashihara More articles by this author Kikuo Nutahara More articles by this author Miho Kojima More articles by this author Takatsugu Okegawa More articles by this author Ichiro Miura More articles by this author Akiomi Miyata More articles by this author Moriaki Kato More articles by this author Hajime Sugisaki More articles by this author Takeshi Tomaru More articles by this author Expand All Advertisement PDF downloadLoading ...
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