Intensification of TEMPO-mediated aerobic alcohol oxidations under three-phase flow conditions
2013; Royal Society of Chemistry; Volume: 15; Issue: 7 Linguagem: Inglês
10.1039/c3gc40159f
ISSN1463-9270
AutoresChristof Aellig, David Scholz, Sabrina Conrad, Ive Hermans,
Tópico(s)Chemical Synthesis and Reactions
ResumoVarious homogeneous and heterogeneous catalytic systems based on 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) and different (co-)oxidants have been reported for the selective oxidation of alcohols. Herein we report the use of a commercially available silica-immobilized TEMPO catalyst, in combination with catalytic amounts of HNO3 as a NOx source under continuous three-phase flow conditions. First the stability of the catalyst was evaluated with benzyl alcohol and the reaction parameters were optimized. Subsequently different substrates were tested, focusing on the oxidation of renewable substrates like lactic acid and 5-hydroxymethylfurfural (HMF).
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