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A Mouse Model of Salmonella Typhi Infection

2012; Cell Press; Volume: 151; Issue: 3 Linguagem: Inglês

10.1016/j.cell.2012.08.042

1097-4172

Ramkumar Mathur, Hyun-Ju Oh, Dekai Zhang, Sung‐Gyoo Park, Jin Jong Seo, A. Alicia Koblansky, Matthew S. Hayden, Sankar Ghosh,

Immune Response and Inflammation

Salmonella spp. are gram-negative flagellated bacteria that can cause food- and waterborne gastroenteritis and typhoid fever in humans. We now report that flagellin from Salmonella spp. is recognized in mouse intestine by Toll-like receptor 11 (TLR11). Absence of TLR11 renders mice more susceptible to infection by S. Typhimurium, with increased dissemination of the bacteria and enhanced lethality. Unlike S. Typhimurium, S. Typhi, a human obligatory pathogen that causes typhoid fever, is normally unable to infect mice. TLR11 is expressed in mice, but not in humans, and remarkably, we find that tlr11−/− mice are efficiently infected with orally administered S. Typhi. We also find that tlr11−/− mice can be immunized against S. Typhi. Therefore, tlr11−/− mice represent a small-animal model for the study of the immune response to S. Typhi and for the development of vaccines against this important human pathogen.