Invariance and restriction toward a limited set of self-antigens characterize neonatal IgM antibody repertoires and prevail in autoreactive repertoires of healthy adults.
1995; National Academy of Sciences; Volume: 92; Issue: 9 Linguagem: Inglês
10.1073/pnas.92.9.3839
ISSN1091-6490
AutoresLuc Mouthon, Alberto Nóbrega, N. Nicolas, Srini V. Kaveri, C Barreau, António Coutinho, M Kazatchkine,
Tópico(s)Immunodeficiency and Autoimmune Disorders
ResumoAnalysis of the reactivity of IgM with self-antigens in tissues by a quantitative immunoblotting technique showed striking invariance among newborns in the human and in the mouse. The self-reactive repertoire of IgM of adults was also markedly conserved; it comprised most anti-self reactivities that prevailed among neonates. Multivariate analysis confirmed the homogeneity of IgM repertoires of neonates toward self- and non-self-antigens. Multivariate analysis discriminated between newborn and adult repertoires for reactivity with two of five sources of self-proteins and with non-self-antigens. Our observations support the concept that naturally activated B lymphocytes are selected early in development and throughout life for reactivity with a restricted set of self-antigens.
Referência(s)