Portal de Periódicos da CAPES

Formation of highly selective and efficient interstrand cross-linking to thymine without photo-irradiation

2009; Royal Society of Chemistry; Issue: 42 Linguagem: Inglês

10.1039/b915381k

1364-548X

Keiichi Hattori, Tomoya Hirohama, Shuhei Imoto, Shuhei Kusano, Fumi Nagatsugi,

RNA Interference and Gene Delivery

Interstrand cross-linking (ICL) forming oligodeoxynucleotides (ODNs) have been expected to ensure the inhibition of gene expression. In this communication, we report a highly efficient and selective ICL reaction to thymine using a 4-amino-2-vinyl-6-oxopyrimidine derivative.