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The preparation of 2,5‐diazabicycio[2.2.2] octane: A bridged piperazine

1974; Wiley; Volume: 11; Issue: 3 Linguagem: Inglês

10.1002/jhet.5570110335

1943-5193

Howard Newman,

Fungal Plant Pathogen Control

Journal of Heterocyclic ChemistryVolume 11, Issue 3 p. 449-451 Note The preparation of 2,5-diazabicycio[2.2.2] octane: A bridged piperazine Howard Newman, Howard Newman Infectious Disease Therapy Section, Lederle Laboratories Division, American Cyanamid Company, Pearl River, New York 10965Search for more papers by this author Howard Newman, Howard Newman Infectious Disease Therapy Section, Lederle Laboratories Division, American Cyanamid Company, Pearl River, New York 10965Search for more papers by this author First published: June 1974 https://doi.org/10.1002/jhet.5570110335Citations: 12AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References 1 See for example W. C. Cutting, “ Handbook of Pharmacology” Appleton-Century-Crofts, New York, N. Y., 1969, 4th Ed. 2 Chem. Abstr., 62, 7761d (1965). (Netherlands Appl., 6,400,946). 3 C. K. Ingold, “ Structure and Mechanism in Organic Chemistry”, Cornell University Press, Ithaca, New York, N. Y., 1953, p. 380. 4 Melting points are uncorrected. The nmr spectra were determined on a Varian HA-100D spectrometer, the mass spectra on an AEI ms-9 instrument. Silica gel G covered micro slides obtained from Analtech Inc., Newark, Delaware were used for thin layer chromatography and spots were visualized with Cl2-tolidine (4a). The absolute methanol used was commercial grade-Magnesium sulfate was used for drying. 4a D. Waldi in “ Thin Layer Chromatography”, 2nd Edition, E. Slahl, Ed., Springer-Verlog, New York, N. Y., 1968, p. 488. 5 “Organic Synthesis”, Coll. Vol. 3, 623. 6 H. R. LeSueur, J. Chem. Soc., 95, 273 (1909). 7 A. Bertho and J. Maier, Ann. Chem., 498, 50 (1932). 8 J. C. Sheehan and W. A. Bolhofer, J. Am. Chem. Soc., 72, 2786 (1950). 9 This yield is somewhat high because of the additional presence of some sodium alkoxide. 10 A short path (ca. 7 cm) distillation head was used. Citing Literature Volume11, Issue3June 1974Pages 449-451 ReferencesRelatedInformation