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BIBTEX RIS

Mitochondrial Energy Metabolism and Redox State in Dyslipidemias

2007; Wiley; Volume: 59; Issue: 4-5 Linguagem: Inglês

10.1080/15216540601178091

1521-6551

Anı́bal E. Vercesi, Roger F. Castilho, Alicia J. Kowaltowski, Helena C.F. Oliveira,

Metabolism and Genetic Disorders

Changes in mitochondrial function are intimately associated with metabolic diseases. Here, we review recent evidence relating alterations in mitochondrial energy metabolism, ion transport and redox state in hypercholesterolemia and hypertriglyceridemia. We focus mainly on changes in mitochondrial respiration, K(+) and Ca(2+) transport, reactive oxygen species generation and susceptibility to mitochondrial permeability transition.