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Chronic idiopathic urticaria: Possible contribution of histamine-releasing factor to pathogenesis

1993; Elsevier BV; Volume: 92; Issue: 1 Linguagem: Inglês

10.1016/0091-6749(93)90047-j

1097-6825

Joël Claveau, Andrea Lavoie, C BRUNET, P BEDARD, Jean‐Louis Hébert,

Dermatology and Skin Diseases

Background: Histamine-releasing factor was recently shown to be clinically relevant in allergic rhinitis and asthma.HRF could also be involved in the pathogeniciv of chronic idiopathic urticaria (CU).The purpose of this study was to investigate the role of HRF in the pathophysiologv of CU.Methods: Blisters were induced on lesional and nonlesional skin of 12 patients with CU and on normal skin of five control subjects.HRF activity and histamine content were measured in all samples recovered from each skin site.Results: Significantly more HRF was found in blister fluids from lesional skin of patients with CU as compared with nonlesional skin and skin of control subjects.In addition, histamine content in blister fluids from affected skin of patients with CU was significantly higher in comparison with both nonlesional skin of patients with CU and skin of control subjects.HRF activity was also higher in blister fluids from nonlesional skin of patients with CU than that of control subjects, in spite of equivalent histamine content.Conclusion: These data suggest that the inflammatory reaction found in CU disease is associated with the cutaneous release of HRF.(J ALLERGY CLIN IMMUNOL 1993;92:132-7.)Key wora%: Chronic idiopathic urticaria, histamine-releasing factor, htstamine contentThe role of histamine in the pathophysiology of chronic idiopathic urticaria (CU) has been established.Interaction between IgE-bound mast cells and allergen is unlikely to be the mechanism by which histamine release occurs because CU does not represent, in most cases, an IgE-mediated allergic reaction.'Therefore a totally different biochemical process could be responsible for localized histamine secretion within separate areas of the skin.There is some evidence to suggest a defective histamine release in CU disease.On the one hand, peripheral blood basophils from patients with CU release significantly less histamine than those from control subjects on challenge with immunologic stimuli.'On the other hand, recent data from our laboratory indicate that