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Impact and progress in small and wide angle X-ray scattering (SAXS and WAXS)

2013; Elsevier BV; Volume: 23; Issue: 5 Linguagem: Inglês

10.1016/j.sbi.2013.06.007

1879-033X

Melissa A. Graewert, Dmitri I. Svergun,

Biochemical and Molecular Research

The advances made in small and wide angle X-ray scattering over the past decades have had a large impact on structural biology. Many new insights into challenging biological probes including large and transient complexes, flexible macromolecules as well as other exciting objects of various sizes were gained with this low resolution technique. Here, we review the recent developments in the experimental setups and in software for data collection and analysis, specifically for hybrid approaches. These progresses have allowed scientists to address a number of intriguing questions which could not be answered with other structural methods alone.