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The effect of propranolol on the serotonin concentration in the portal plasma after vagal nerve stimulation in the cat

1979; Wiley; Volume: 107; Issue: 4 Linguagem: Inglês

10.1111/j.1748-1716.1979.tb06483.x

1365-201X

Gösta Pettersson, Håkan Ahlman, Hemendra N. Bhargava, Annica Dahlström, J Kewenter, Inger Larsson, John K. Siepler,

Urinary Bladder and Prostate Research

Efferent cervical vagal nerve stimulation in the cat caused a marked increase of the portal plasma 5-HT concentration. This increase was more than two-fold within 15 min of stimulation. After cessation of stimulation portal plasma 5-HT returned to basal levels within 10 min. Treatment with the beta-adrenoceptor antagonist propranolol, in various doses (0.1-2 mg/kg b.wt.), did not abolish but significantly reduced the response to vagal stimulation, particularly during the final part of the stimulation period. The results confirm the existence of a beta-adrenoceptor-mediated release of 5-HT, but also suggest that other mechanisms for 5-HT release may be involved in the response on vagal nerve stimulation.