Vitamin D deficiency in Crohn's disease and healthy controls: A prospective case–control study in the Netherlands
2014; Oxford University Press; Volume: 8; Issue: 10 Linguagem: Inglês
10.1016/j.crohns.2014.03.004
ISSN1876-4479
AutoresJessica R. de Bruyn, Rosanne van Heeckeren, Cyriel Y. Ponsioen, Gijs R. van den Brink, Mark Löwenberg, Albert J. Bredenoord, Gerard Frijstein, Geert R. D’Haens,
Tópico(s)Endometriosis Research and Treatment
ResumoBackground and aims: Vitamin D deficiency has been observed in a wide range of medical conditions including Crohn's disease (CD). We aimed to assess whether CD patients have lower vitamin D levels than healthy controls, and to determine risk factors for vitamin D deficiency. Methods: 25(OH)D was measured by chemiluminescent immunoassay in serum obtained from 101 CD patients and 41 controls. Demographics, sunlight exposure, dietary vitamin D intake, comorbidities and medication were recorded using validated questionnaires. In CD patients the Harvey–Bradshaw index, Montreal classification and surgical resections were also evaluated. 25(OH)D levels of >75 nmol/L, between 50 and 75 nmol/L and <50 nmol/L were considered as normal, suboptimal and deficient, respectively.
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