A Ser678Pro Substitution in Fks1p Confers Resistance to Echinocandin Drugs in Aspergillus fumigatus
2007; American Society for Microbiology; Volume: 51; Issue: 11 Linguagem: Inglês
10.1128/aac.00917-07
ISSN1098-6596
AutoresEleusa Maria Ferreira Rocha, Guillermo García‐Effrón, Steven Park, David S. Perlin,
Tópico(s)Microbial Natural Products and Biosynthesis
ResumoAn S678P substitution in Fks1p, the major subunit of glucan synthase, was sufficient to confer echinocandin resistance in Aspergillus fumigatus. The equivalent mutation in Candida spp. has been implicated in echinocandin resistance. This work demonstrates that modification of Fks1p is a conserved mechanism for echinocandin resistance in pathogenic fungi.
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