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Screening for multiple hereditary hypercoagulability factors using the amplification refractory mutation system

2003; Elsevier BV; Volume: 111; Issue: 1-2 Linguagem: Inglês

10.1016/j.thromres.2003.08.024

1879-2472

Berthold Hoppe, Guido Heymann, Jürgen Koscielny, Peter Hellstern, H. Kiesewetter, Abdulgabar Salama,

Hemophilia Treatment and Research

Many hereditary factors have been implicated in the development of arterial and/or venous thromboembolic diseases. A number of these risk factors can be identified by the amplification refractory mutation system (ARMS). However, the underlying technical conditions for performing ARMS are highly variable, and depend on which risk factors are being analyzed. We have now developed a novel ARMS-based system to simultaneously screen for multiple hypercoagulability factors under identical PCR conditions. This can greatly simplify the process of screening for hereditary hypercoagulability.