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GENERALISED GLYCOGENOSIS IN BRAHMAN CATTLE

1981; Wiley; Volume: 57; Issue: 5 Linguagem: Inglês

10.1111/j.1751-0813.1981.tb02666.x

1751-0813

Brendan O’Sullivan, P. J. Healy, Ian R. Fraser, R. E. Nieper, Rebecca Whittle, Catherine Sewell,

Calpain Protease Function and Regulation

SUMMARY Generalised glycogenosis was diagnosed in Brahman cattle on 4 Queensland properties on the basis of clinical observations and pathological and biochemical findings. The disease presented as a problem of ill‐thrift and poor growth rate in calves which eventually showed nervous signs. Histologically there was vacuolation in the cells of the central nervous system, heart and muscular tissues. Biochemical assay of liver and blood mononuclear cells demonstrated a deficiency of α‐glucosidase. Parents of affected calves had approximately half the α‐glucosidase activity of that found in normal cattle.