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Fire–diffuse–fire model of dynamics of intracellular calcium waves

1999; National Academy of Sciences; Volume: 96; Issue: 11 Linguagem: Inglês

10.1073/pnas.96.11.6060

1091-6490

Silvina Ponce Dawson, Joel Keizer, John E. Pearson,

Plant Reproductive Biology

When Ca 2+ is released from internal stores in living cells, the resulting wave of increased concentration can travel without deformation (continuous propagation) or with burst-like behavior (saltatory propagation). We analyze the “fire–diffuse–fire” model in order to illuminate the differences between these two modes of propagation. We show that the Ca 2+ release wave in immature Xenopus oocytes and cardiac myocytes is saltatory, whereas the fertilization wave in the mature oocyte is continuous.