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Body Composition and Serum Prostate-Specific Antigen: Review and Findings from Flint Men’s Health Study

2008; Elsevier BV; Volume: 71; Issue: 4 Linguagem: Inglês

10.1016/j.urology.2007.11.049

1527-9995

Jennifer Beebe‐Dimmer, Gary J. Faerber, Hal Morgenstern, David Werny, Kirk J. Wojno, Bronwen A. Halstead-Nussloch, Kathleen A. Cooney,

Birth, Development, and Health

Recent studies have suggested that obesity is associated with lower serum prostate-specific antigen levels, perhaps influencing the recommendation for prostate biopsy and potentially explaining part of the observed poorer prognosis among obese men. African-American men have the greatest rates of prostate cancer and are more likely to die of the disease, making early detection a priority in this group. We present findings from the Flint Men's Health Study, a study of African-American men, that are consistent with most studies suggesting that overweight men have prostate-specific antigen levels that are 0.15 to 0.30 ng/mL lower than those who are not overweight. We have coupled our results with a systematic review of publications in this area. Recent studies have suggested that obesity is associated with lower serum prostate-specific antigen levels, perhaps influencing the recommendation for prostate biopsy and potentially explaining part of the observed poorer prognosis among obese men. African-American men have the greatest rates of prostate cancer and are more likely to die of the disease, making early detection a priority in this group. We present findings from the Flint Men's Health Study, a study of African-American men, that are consistent with most studies suggesting that overweight men have prostate-specific antigen levels that are 0.15 to 0.30 ng/mL lower than those who are not overweight. We have coupled our results with a systematic review of publications in this area.