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Anti-TNF therapy using etanercept suppresses degenerative and inflammatory changes in skeletal muscle of older SJL/J mice

2011; Elsevier BV; Volume: 90; Issue: 3 Linguagem: Inglês

10.1016/j.yexmp.2011.02.003

1096-0945

Hiroshi Nemoto, Shingo Konno, Hideki Sugimoto, Hiroshi Nakazora, Nobuatsu Nomoto, Mayumi Murata, Hisao Kitazono, Toshiki Fujioka,

Viral Infections and Immunology Research

Limb-girdle muscular dystrophy 2B and Miyoshi myopathy are characterized by muscle fiber necrosis caused by a defect in dysferlin and inflammatory changes. SJL/J mice are deficient in dysferlin and display severe inflammatory changes, most notably the presence of cytokines, which may be related to destruction of the sarcolemma. We tested the hypothesis that tumor necrosis factor (TNF) contributes to myofibril necrosis. Administration of etanercept, an agent that blocks TNF, resulted in dose-dependent reductions in inflammatory change, necrosis, and fatty/fibrous change. These findings indicate that TNF does indeed play a role in the damage to muscle in SJL/J mice and that etanercept has the potential to reduce such damage.