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The Synergistic Purgative Action of Aloe-emodin Anthrone and Rhein Anthrone in Mice: Synergism in Large Intestinal Propulsion and Water Secretion

1997; Oxford University Press; Volume: 49; Issue: 1 Linguagem: Inglês

10.1111/j.2042-7158.1997.tb06745.x

2042-7158

Teruyo Yagi, Kazuko Yamauchi, Shigeaki Kuwano,

Natural Compound Pharmacology Studies

This study aimed to explore the mechanism involved in the synergistic purgative action of aloe-emodin anthrone and rhein anthrone, the active metabolites of sennoside C. Aloe-emodin anthrone and rhein anthrone, and their equimolar mixture, induced excretion of an approximately equal number of faeces by intracaecal administration at a dose of 23.2 mumol kg-1 in mice (= 1.0 standard dose). The number of wet faeces induced by aloe-emodin anthrone was less than those of rhein anthrone and the mixture. At the same dose, rhein anthrone and the mixture significantly stimulated large intestinal propulsion, though aloe-emodin anthrone had little stimulatory effect. Aloe-emodin anthrone and rhein anthrone decreased net water absorption but could not reverse it to the net secretion at 1/2 dose. The mixture significantly decreased net water absorption and reversed it to the net secretion at this dose. These anthrones did not stimulate mucus secretion in the colon at 1/2 dose. We concluded that the synergistic purgative effect of aloe-emodin anthrone and rhein anthrone in mice results from synergistic stimulation of large intestinal transit and large intestinal water secretion.