Increased temporal cortex CREB concentrations and antidepressant treatment in major depression
1998; Elsevier BV; Volume: 352; Issue: 9142 Linguagem: Inglês
10.1016/s0140-6736(05)79827-5
ISSN1474-547X
AutoresL. Trevor Young, Dar Dowlatshahi, Glenda MacQueen, Jun Feng Wang,
Tópico(s)Nuclear Receptors and Signaling
ResumoBlunted brain cyclic adenosine monophosphate (cAMP) signalling is purported to occur in major depressive disorder (MDD). 1 Duman RS Heninger GR Nestler EJ A molecular and cellular theory of depression. Arch Gen Psychiatry. 1997; 54: 597-606 Crossref PubMed Scopus (1866) Google Scholar Furthermore, antidepressants increase concentrations of the critical downstream target of cAMP signalling, cAMP regulatory element protein (CREB). 2 Nibuya M Nestler EJ Duman RS Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus. J Neurosci. 1996; 16: 2365-2372 Crossref PubMed Google Scholar CREB is a transcription factor involved in regulation of genes important for neuronal regulation and survival of proteins such as brain-derived neurotropic factor. This increase in CREB may underlie the long-term changes thought to delay the therapeutic effects of antidepressants. These hypotheses are intriguing but are derived from animal studies. We investigated CREB concentrations in untreated patients with MDD and those treated with antidepressants.
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