Revisão Acesso aberto Revisado por pares

Pathophysiological aspects of acute experimental allergic encephalomyelitis

1988; Wiley; Volume: 78; Linguagem: Inglês

10.1111/j.1600-0404.1988.tb08016.x

ISSN

1600-0404

Autores

Marianne Juhler,

Tópico(s)

S100 Proteins and Annexins

Resumo

Acta Neurologica ScandinavicaVolume 78, Issue s119 p. 1-21 Pathophysiological aspects of acute experimental allergic encephalomyelitis Marianne Juhler, Marianne Juhler Department of Neurology, Rigshospitalet, Copenhagen, DenmarkSearch for more papers by this author Marianne Juhler, Marianne Juhler Department of Neurology, Rigshospitalet, Copenhagen, DenmarkSearch for more papers by this author First published: December 1988 https://doi.org/10.1111/j.1600-0404.1988.tb08016.xCitations: 14AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL References 1 Rivers TM, Sprunt DH, Berry GP. Observations on attempts to produce acute disseminated encephalomyelitis in monkeys. J Exp Med 1933: 58: 39 – 54. 2 Kabat EA, Wolff A., Bezer AE. Rapid production of acute disseminated encephalomyelitis in rhesus mankeys by injektion of brain tissue with adjuvants. Science 1946: 104: 362 – 363. 3 Paterson PY, Drobish DG, Hansen MA, Jacobs AF. Induction of experimental allergic encephalomyelitis in Lewis rats. Int Arch All 1970: 27: 26 – 40. 4 Juhler M., Barry DI, Offner H., Konat G., Klinken L., Paulson OB. Blood-brain and blood-spinal cord barrier permeability during the course of experimental allergic encephalomyelitis in the rat. Brain Research 1984: 302: 347 – 355. 5 Oldendorf WH, Towner HF. Blood-brain barrier and DNA changes during the evolution of experimental allergic encephalomyelitis. J Neuropath Exp Neurol 1974: 33: 616 – 631. 6 RD Simmons, CCA Bernard, Rosbo N. Kerlero, PR. Carnegie Criteria for an adequate explanation of typical clinical signs of EAE in rodents. In EC Alvord, MW Kies, AJ Suckling (eds.). Experimental allergic encephalomyelitis - a useful model for multiple sclerosis. Progress in clinical and biological research, vol. 146, Alan R. Liss, New York 1984: 23 – 29. 7 Simmons RD, Bernard CCA, Singer G., Carnegie PR. Experimental autoimmune encephalomyelitis. An anatomically based explanation of clinical progression in rodents. J Neuroimmunol 1982: 3: 307 – 318. 8 Juhler M., Blasberg RG, Fenstermacher JD, Patlak CS, Paulson OB. A spatial analysis of the blood-brain barrier damage in experimental allergic encephalomyelitis. J Cerebral Blood Flow Metabol 1985: 5: 545 – 553. 9 Lampert PW. Pathological implications of immunological disease in the central nervous system. In B.H. Waksman, (Ed.) Immunoneuropathology, Saunders, London , Philadelphia , Toronto 1982: 347 – 369. 10 Traugott U., Shevach E., Chiba J., Stone SH, Raine CS. Acute experimental autoimmune encephalomyelitis: T-and B-cell distribution within the target organ. Cell Immunol 1982: 70: 345 – 356. 11 Juhler M., Laursen H., Barry DI. The distribution of immunoglobulins and albumin in the central nervous system in acute experimental encephalomyelitis. Acta Neurol Scand 1985:1986: 73: 119 – 124. 12 Kristenson K., Wisniewsky HM, Bornstein MB. About demyelinating properties of humoral antibodies in experimental allergic encephalomyelitis. Acta neuropath 1976: 36: 307 – 314. 13 Lampert PW, Carpenter S. Electron microscopic studies on the vascular permeability and the mechanism of demyelination in experimental allergic encephalomyelitis. J Neuropath Exp Neurol 1965: 24: 11 – 24. 14 Alvord EC, Kies MW, Suckling AJ. Experimental allergic encephalomyelitis. A useful model for multiple sclerosis. Progress in clinical and biological research, vol 146, Alan R. Liss, Inc., New York 1984. 15 BH Waksman (ed.). Immunoneuropathology, Clinics in immunology and allergy, vol. 24, W.B. Saunders, London , Philadelphia , Toronto , 1982. 16 Paterson PY. Transfer of allergic encephalomyelitis in rats by means of lymph node cells. J Exp Med 1960: 111: 119 – 135. 17 Condie RM, Good RA. Experimental allergic encephalomyelitis. Its production, prevention and pathology as studied by light and electron microscopy. I: SR Kerey, ed. The biology of myelin. New York :Hoeber-Harper 1959: pp 321 – 332. 18 Sriram S., Roberts CA. Treatment of established chronic relapsing ecperimental allergic encephalomyelitis with anti-L3T4 antibodies. J Immunol 1986: 136: 4464 – 4469. 19 Gonatas NK, Howard JC. Inhibition of experimental allergic encephalomyelitis in rats severely depleted of T-cells. Science, 1974: 186: 839. 20 Swanborg RH. Autoimmune effector cells. V.A. monoclonal antibody specific for rat helper T-lymphocytes inhibits adoptive transfer of autoimmune encephalomyelitis. J Immunol 1983: 130: 1503 – 1505. 21 Juhler M., Neuwelt EA. the blood-brain barrier and the immunesystem. In: EA Neuwelt (ed). The impact of the blood-brain barrier and its manipulation. In press, Plenum Press. 22 Matsumoto Y., Fujiwara M. In situ localisation og class I and II major histocompatibility antigens in the rat central nervous system during experimental allergic encephalomyelitis. An immunohistochemical study. J Neuroimmunol 1986: 12: 265 – 277. 23 Vass K., Lassmann H., Wekerle H., Wisniewski HM. The distribution of Ia antigen in the lesions of rat acute experimental allergic encephalomyelitis. Acta neuropathol (Berlin) 1986: 70: 149 – 160. 24 AA Vandenbark, JCMY Raus (eds). Immunoregulatory process in experimental allergic encephalomyelitis and multiple sclerosis. Elsevier Sci Publ Co, Amsterdam 1984. 25 Hickey WF, Osborn JP, Kirby WM. Expression of Ia molecules by astrocytes during acute experimental allergic encephalomyelitis in the Lewis rat. Cell Immunol 1985: 91: 528 – 535. 26 Werdelin O., McCluskey RT. The nature and specificity of mononuclear cells in experimental autoimmune inflammation and the mechanism leading to their accumulation. J Exp Med 1971: 133: 1242 – 1249. 27 Willenborg DO. Transfer of lesions of allergic encephalomyelitis in sheep with cell-free lymph from animals sensitized with homologous spinal cord plus adjuvant. Scand J Immunol 1982: 16: 437 – 441. 28 Willenborg DO, Prowse SJ. Immunoglobulin-deficient rats fail to develop experimental allergic encephalomyelitis. J Neuroimmunol 1983: 5: 99 – 109. 29 Gausas J., Paterson PY, Day ED, dal Canto MC. Intact B-cell activity is essential for complete expression of experimental allergic encephalomyelitis in Lewis rats. Cell Immunol 1982: 72: 360 – 366. 30 Lemire JM, Weigle WO. Passive transfer of experimental allergic encephalomyelitis by myelin basic protein specific L3T44T-cell clones possessing several functions. J Immunol 1986: 137: 3169 – 3174. 31 Brosnan CF, Traugott U., Raine CS. Analysis of humoral and cellular events and the role of lipid haptens during CNS demyelination. Acta Neuropathol. (Berl.), 1983:suppl. 9: 59 – 70. 32 Liu WT, Vanguri P., Shin ML. Studies on demyelination in vitro: the requirement of membrane attack components of the complement system. J Immunol 1983: 131: 772 – 778. 33 Stoner GL, Brosnan CF, Wisniewsky HM, Bloom BR. Studies on demyelination by activated lymphocytes in the rabbit eye. J Immunol 1977: 118: 2094 – 2102. 34 Mehta PD, Lassmann H., Wisniewski HM. Immunologic studies of chronic relapsing EAE in guineapigs: similarities to multiple sclerosis. J Immunol 1981: 127: 334 – 338. 35 Grundke-Iqbal I., Lassmann H., Wisniewsky HM. Chronic relapsing experimental allergic encephalomyelitis. Immuno-histochemical studies. Arch Neurol 1980: 37: 651 – 656. 36 Brosnan CF, Bornstein MB, Bloom BR. The effects of macrophage depletion on the clinical and pathologic expression of experimental allergic encephalomyelitis. J Immunol 1981: 126: 614 – 620. 37 Kies MW. Chemical studies on an encephalitogenic protein from guinea pig brain. Am. N.Y. Acad Sci 1965: 122: 161 – 169. 38 Vandenbark AA, Offner H., Reslef T., Fritz R., Chon CH, Cohen IR. Specificity of T-lymphocyte lines for peptides of myelin basic protein. J Immunol 1985: 135: 229 – 233. 39 Hashim GA. Neural antigens and the development of antoimmunity. J Immunol 1985: 135 (suppl): 838 – 842. 40 Wisniewsky HM, Lassmann H., Brosnan CF, Mehta PD, Lidsky AA, Madrid RE. Multiple Sclerosis: Immunological and experimental aspects. In: W.B. Matthews, C.H. Glaser (eds). Recent advances in neurology 3, Churchill Livingstone, Edinburgh , London , Melbourne , New York 1982:pp 95 – 124. 41 Yoshimura T., Kumishita T., Sakai K., Endoh M., Namikawa T., Tabira T. Chronic experimental allergic encephalomyelitis in guineapigs induced by proteolipid protein. J Neurol Sci 1985: 69: 47 – 58. 42 Yonezawa T. Circulating myelinotoxic factors in human and experimental demyelinative tissue. Acta Neuropath (Berl.), 1983: suppl 9: 47 – 58. 43 Maggio B., Cumar FA, Roth GA, Montferran CG, Fidelio GD. Neurochemical and model membrane studies in demyelinating diseases. Acta Neuropathol., (Berl.) 1983: suppl 9: 71 – 85. 44 Bradbury M. The concept of a blood-brain barrier, John Wiley. Chichester-New York-Brisbane-Toronto, 1979: pp. 84 – 137. 45 Brightman MW, Reese TS. Junctions between intimately opposed cell membranes in the vertebrate brain. J Cell Bio 1969: 40: 648 – 677. 46 Rapoport SI. Blood-brain barrier in physiology and medicine. New York , Raven Press 1976: pp 43 – 127. 47 Lajtha A. Protein metabolism of the nervous system. Neurobiology 1964: 1 – 98. 48 Smith ME. The turnover of myelin proteins. Neurobiology, 1972: 2: 35 – 40. 49 Klatzo I., Miquel J., Ferris PJ, Prokop JD and Smith DE. Observations on the passage of flourescin labelled proteins (FLSP) from the cerebrospinal fluid. J Neuropath Exp Neurol 1964: 23: 18 – 35. 50 Simon J., Anzil AP. Immunohistological evidence of perivascular localization of basic protein in early development of experimental allergic encephalomyelitis. Acta Neuropath. (Berl.), 1974: 27: 33 – 42. 51 Wiesniewsky HM, Lassmann H. Etiology and patho-genesis of monophasic and relapsing inflammatory demyelination human and experimental. Acta Neuropath. (Berlin) 1983: suppl. IX: 21 – 31. 52 Daniel PM, Lam DKC, Pratt OE. Changes in the effectiveness of the blood-brain and blood-spinal cord barriers in experimental allergic encephalomyelitis. J Neurol Sci 1981: 51: 2119. 53 Olsson Y. Topographical differences in the vascular permeability of the peripheral nervous system. Acta Neuropath 1968: 10: 26 – 33. 54 Levine S., Sowinsky R. Experimental allergic encephalomyelitis: simple method for producing the localized form. J Immunol Methods 1982: 54: 355 – 360. 55 Pender MP, Sears TA. The pathophysiology of acute experimental allergic encephalomyelitis in the rabbit. Brain 1984: 107: 699 – 726. 56 Barlow CF. A study of abnormal blood-brain barrier permeability in experimental allergic encephalomyelitis. J Neuropath Exp Neurol 1956: 15: 196 – 208. 57 Cutler RWP, Lorenzo AV, Barlow CF. Brain vascular permeability ot I125 gamma globulin and leucocytes in allergic encephalomyelitis. J Neuropath Exp Neurol 1967: 26: 558 – 71. 58 Oldstone MD, Dixon FJ. Immunohistochemical study of allergic encephalomyelitis. Amer J Path 1968: 52: 251 – 263. 59 Vulpe MD, Hawkins MA, Rodzilsky B. Permeability of cerebral blood vessels in experimental allergic encephalomyelitis studied by radioactive iodinated bovine albumine by radio iodinated bovine albumin. J Neurol 1960: 10: 171 – 177. 60 Broman T. The Permeability of the Cerebrospinal Vessels in Normal and Pathological Conditions. Munksgaard, Copenhagen , 1949: pp. 61 – 69. 61 Leibowitz S. Cerebral vascular permeability in experimental allergic encephalomyelitis. Neuropath Pol 1969: 7: 303 – 309. 62 Leibowitz S., Kennedy L. Cerebral vascular permeability and cellular infiltration in experimental allergic encephalomyelitis. Immunol 1972: 22: 859 – 869. 63 Rogers AW. Practical autoradiography. Amsherham Reviews 20, Buckinghamshire, 1979. 64 Ohno K., Pettigrew KD, Rapoport SI. Lower limits of cerebrovascular permeability to nonelectrolytes in the conscious rat. Amer J Physiol 1978: 253: H299 – H307. 65 Westergaard E. The blood-brain barrier to horseradish peroxidase under normal and experimental conditions. Acta Neuropath., (Berlin) 1977: 39: 181 – 188. 66 Pappenheimer JR. In: Crone C., Lassen NA (Eds.). Capillary Permeability: the Transfer of Molecules Between Capillary Blood and Tissue, Munksgaard , Copenhagen, 1970: pp 278 – 290. 67 Hirano A., Dembitzer HM, Becker NH, Levine S., Zimmermann HM. Fine structural alterations of the blood-brain barrier in experimental allergic encephalomyelitis. J Neuropath Exp Neurol 1970: 29: 432 – 440. 68 Lassmann H. Comparative neuropathology of chronic experimental allergic encephalomyelitis and multiple sclerosis. Schriftenreihe Neurologie, vol. 25. Berlin , Springer 1983. 69 Wisniewsky HM, Lossinsky AS, Moretz RC, Vorbrodt AW, Lassmann H., Carp RI. Increased blood-brain barrier permeability in scrapie infected mice. J Neuropath Exp Neurol 1983: 42: 615 – 626. 70 Siesjö BK. Brain energy metabolism. New York , John Wiley and Sons, 1978. 71 Sokoloff L. Localization of functional activity in the central nervous system by measurement of glucose utilization with radioactive deoxyglucose. J Cereb Blood Flow Metabol 1981: 1: 7 – 36. 72 Smith ME. Glucose metabolism of central nervous tissues in rats with experimental allergic encephalomyelitis. Nature 1966: 209: 1031 – 1032. 73 Di Rocco RJ, Hashim GA. Increased glucose utilization associated with inflammatory brain lesions of experimental allergic encephalomyelitis. Neurosci Lett 1983: 37: 105 – 10. 74 Juhler M., Paulson OB. Regional cerebral blood flow in acute experimental allergic encephalomyelitis. Brain Research 1986: 363: 272 – 278. 75 Juhler M. Simultaneous determination of regional cerebral blood flow, glucose metabolism and pH in acute experimental allergic encephalomyelitis. J Cereb Blood Flow Metabol 1987: 7: 578 – 584. 76 Pulsinelli WA, Levy DE, Duffy TE. Regional cerebral blood flow and glucose metabolism following transient forebrain ischemia. Ann Neurol 1982: 11: 499 – 509. 77 Saragea M., Clopotaru M., Sica M., Vladutiu A., Negru T., Rotaru N. Biochemical changes occurring in animals with EAE. Med Pharmacol Exp 1965: 13: 74 – 80. 78 Roizin L. Some basic principles of molecular pathology. J Neuropath Exp Neurol 1964: 23: 209 – 252. 79 Lassen NA, Perl W. Tracer Kinetic methods in medical physiology. Raven Press, New York 1979. 80 Patlak CS, Blasberg RG, Fenstermacher JD. Graphical evaluation of blood-to-brain transfer constants from multipletime uptake data. J Cereb Blood Flow Metabol 1983: 3: 119 – 135. 81 Gjedde A. Calculation of cerebral glucose phosphorylation from brain uptake of glucose analogs in vivo: a reexamination. Brain Research Reviews, 1982: 4: 237 – 274. 82 Lassen NA, Gjedde A. Kinetic analysis of the uptake of glucose and some of its analogs in die brain using the single capillary model: comments on some points of controversy. In: Tracer kinetics and physiologic modelling. Lecture notes in biomathematics. Vol. 48 ( R.M. Lambrecht, A. Resigno, eds.) Berlin , Springer 1983: pp. 384 – 407. 83 Blasberg RG, Fenstermacher JD, Patlak CS. Transport of alpha-amino isobutyric acid across brain capillary and cellular membranes. J Cereb Blood Flow Metabol 1983: 3: 8 – 32. 84 Fenstermacher JD, Blasberg RG, Patlak CS. Methods for quantifying the transport of drugs across brain barrier systems. Pharmac Ther 1981: 14: 217 – 48. 85 Sokoloff L., Reivich M., Kennedy C., des Rosiers MH, Patlak CS, Pettigrew KD, Sakurada O., Shinohara M. The 14-C deoxyglucose method for measurement of local cerebral glucose utilization: Theory, procedure and normal values in the conscious and anesthetized albino rat. J Neurochem 1977: 28: 897 – 916. 86 Sokoloff L. The 14-C deoxyglucose method: four years later. In: Cerebral blood flow and metabolism. Acta Neurol Scand Suppl ( F. Gotoh, H. Nagai, Y. Tazaki, eds.) Copenhagen , Munksgaard 1979: pp 640 – 649. 87 Kelly PAT, McCulloch JA. Critical appraisal of semiquantitative analysis of 2-deoxyglucose autoradiograms. Brain Research, 1983: 269: 165 – 167. 88 Blasberg RG, Groothuis D., Molnar P. Application of quantitative autoradiographic measurements in experimental brain tumor models. Sem Neurol 1981: 1: 203 – 221. 89 Smith CB. Localization of activity-associated changes in metabolism of the central nervous system with the deoxyglucose method:prospects for cellular resolution. In JL Barker and JF McKelvey (eds). Current methods in cellular neurobiology. New York , John Wiley & Sons 1983: pp 270 – 317. 90 Juhler M., Diemer NH. A Method for 14C and 3H double label autoradiography. J Cereb Blood Flow Metabol 1987: 7: 572 – 577. 91 Diemer NH, Rosenørn J. Determination of local cerebral blood flow and glucose metabolism or transferby means of a double autoradiographic method. J Cereb Blood Flow Metabol suppl 1981: 1: S72 – S73. 92 Lear JL, Jones SC, Greenberg JM, Fedora TJ, Reivich M. Use of 123-I and 14-C in a double radionuclide autoradiographic technique for simultaneous measurement of LCBF and LCMR gl. Theory and method. Stroke 1981: 12: 589 – 597. 93 Mies G., Niebuhr I., Hossmann KA. Simultaneous measurement of blood flow and glucose metabolism by autoradiographic techniques. Stroke 1981: 12: 581 – 588. 94 Mies G., Bodsch W., Paschen W., Hossmann KA. Triple tracer autoradiography of cerebral blood flow, glucose utilization andprotein syndiesis in rat brain. J Cereb Blood Flow Metabol 1986: 6: 59 – 70. 95 Nedergaard M., Gjedde A., Diemer NH. Focal ischemia of the rat brain: autoradiographic determination of cerebral glucose utilization, glucose content, and blood flow. J Cereb Blood Flow Metabol 1986: 6: 414 – 424. 96 Arnason, BGW. Neuroimmunology. New Engl J Med 1987: 316: 406 – 408. Citing Literature Volume78, Issues119December 1988Pages 1-21 ReferencesRelatedInformation

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