Isoelectric focusing herpes simplex virus-gB overlay study in brainstem encephalitis
2009; Wiley; Volume: 82; Issue: 6 Linguagem: Inglês
10.1111/j.1600-0404.1990.tb03318.x
ISSN1600-0404
AutoresGianvito Martino, Luigi M.E. Grimaldi, Diego Franciotta, G. Piccolo, Raffaele Brustia, Lorenzo Minali, G.V. Melzi d’Eril,
Tópico(s)Viral Infections and Immunology Research
ResumoAbstract We report a case of herpetic brainstem encephalitis (HBE) retrospectively diagnosed in an adult patient. Conventional immunovirological studies failed to disclose the etiology of this patient's affection. An isoelectric focusing-antigen overlay (IEF-O) technique showed that the target of one of the four cerebrospinal fluid oligoclonal bands was herpes simplex virus (HSV)-1 glycoprotein B, indicating a specific anti-HSV immunoresponse restricted to the CNS. IEF-O may represent a useful support for in vivo diagnosis of HBE.
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