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Further validation of the IBS-QOL: a disease-specific quality-of-life questionnaire

2000; Lippincott Williams & Wilkins; Volume: 95; Issue: 4 Linguagem: Inglês

10.1111/j.1572-0241.2000.01941.x

1572-0241

Douglas A. Drossman, Donald L. Patrick, William E. Whitehead, Brenda B. Toner, Nicholas E. Diamant, Yuming Hu, Huanguang Jia, Shrikant I. Bangdiwala,

Therapeutic Uses of Natural Elements

There has been growing interest in the investigation of health-related quality of life (HRQOL) among patients with gastrointestinal (GI) disorders. We recently reported on the development and preliminary validation of the IBS-QOL, a specific quality-of-life measure for irritable bowel syndrome (IBS). The aim of this study was to determine the longitudinal construct validity (responsiveness) of the IBS-QOL.Female patients enrolled in a multicenter treatment trial for functional bowel disorders were studied pre- and posttreatment with the IBS-QOL and other health status measures. Based on the response to treatment for several variables (pain/14-day score, daily function, and days in bed/3 months), patients were stratified into Responders, Partial Responders, and Nonresponders. Change scores in the IBS-QOL were then statistically compared with changes in the other variables to determine their correlation and whether Responders were significantly different from non- and Partial Responders on the IBS-QOL.There was a significant correlation between change scores on the IBS-QOL and the other measures of treatment effect (Pain/14 days, r = 0.25, p < 0.002; Sickness Impact Profile [SIP] Total Score, r = 0.28, p < 0.0004). In addition, the IBS-QOL scores significantly differentiated Responders from Nonresponders for most of the variables tested (regression trend test for Pain/14 days, p < 0.04; SIP Total, p < 0.0001; SIP Physical, p < 0.0001; SIP Psychosocial, p < 0.002, and SIP Eating, p < 0.04).The IBS-QOL is responsive to treatment in a referral-based clinical population of patients with functional bowel disorders.