Artigo Acesso aberto Revisado por pares

Hemochromatosis: How much iron is too much?

1986; Lippincott Williams & Wilkins; Volume: 6; Issue: 1 Linguagem: Inglês

10.1002/hep.1840060128

ISSN

1527-3350

Autores

Anthony S. Tavill, Bruce R. Bacon,

Tópico(s)

Trace Elements in Health

Resumo

HepatologyVolume 6, Issue 1 p. 142-145 EditorialFree Access Hemochromatosis: How much iron is too much? Anthony S. Tavill M.D., Corresponding Author Anthony S. Tavill M.D. Case Western Reserve University Cleveland Metropolitan General Hospital Cleveland, OH 44109Cleveland Metropolitan General Hospital, 3395 Scranton Road, Cleveland, Ohio 44109===Search for more papers by this authorBruce R. Bacon, Bruce R. Bacon Case Western Reserve University Cleveland Metropolitan General Hospital Cleveland, OH 44109Search for more papers by this author Anthony S. Tavill M.D., Corresponding Author Anthony S. Tavill M.D. Case Western Reserve University Cleveland Metropolitan General Hospital Cleveland, OH 44109Cleveland Metropolitan General Hospital, 3395 Scranton Road, Cleveland, Ohio 44109===Search for more papers by this authorBruce R. Bacon, Bruce R. Bacon Case Western Reserve University Cleveland Metropolitan General Hospital Cleveland, OH 44109Search for more papers by this author First published: January/February 1986 https://doi.org/10.1002/hep.1840060128Citations: 20AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References 1 Bassett ML, Halliday JW, Powell LW. Value of hepatic iron measurements in early hemochromatosis and determination of the critical iron level associated with fibrosis. Hepatology 1986; 6: 24–29 2 Bomford A, Williams R. Long-term results of venesection therapy in idiopathic hemochromatosis. Q J Med NS 1976; 45: 611–623. 3 Milder MS, Cook JD, Stray S, et al. Idiopathic hemochromatosis, an interim report. Medicine 1980; 59: 39–49. 4 Cartwright GE, Edwards CQ, Kravitz K, et al. Hereditary hemochromatosis. Phenotypic expression of the disease. N Engl J Med 1979; 301: 175–179. 5 Edwards CQ, Cartwright GE, Skolnick MH, et al. Homozygosity for hemochromatosis: clinical manifestations. Ann Intern Med 1980; 93: 519–525. 6 Simon M, Bourel M, Genetet B, et al. Idiopathic hemochromatosis: demonstration of recessive transmission and early detection by family HLA typing. N Engl J Med 1977; 297: 1017–1021. 7 Bassett ML, Halliday JW, Ferris RA, et al. Diagnosis of hemochromatosis in young subjects: predictive accuracy of biochemical screening tests. Gastroenterology 1984; 87: 628–633. 8 Isaacson C, Seftel HC, Keeley KJ, et al. Siderosis in the Bantu: the relationship between hepatic iron overload and cirrhosis. J Lab Clin Med 1961; 58: 845–953. 9 Risdon RA, Barry M, Flynn DM. Transfusion iron overload: the relationship between tissue iron concentration and hepatic fibrosis in thalassemia. J Pathol 1975; 116: 83–95. 10 Barry M, Flynn DM, Letsky EA, et al. Long-term chelation therapy in thalassemia major: effect on liver iron concentration, liver histology and clinical progress. Br Med J 1975; 2: 16–20. 11 Cohen A, Martin M, Schwartz E. Depletion of excessive liver iron stores with desferrioxamine. Br J Haematol 1984; 58: 369–373. 12 Bacon BR, Tavill AS, Brittenham GM, et al. Hepatic lipid peroxidation in vivo in rats with chronic iron overload. J Clin Invest 1983; 71: 429–439. 13 Powell LW. The role of alcoholism in hepatic iron storage disease. Ann NY Acad Sci 1975; 252: 124–134. 14 Valenzuela A, Fernandez V, Videla LA. Hepatic and biliary levels of glutathione and lipid peroxides following iron overload in the rat: effect of simultaneous ethanol administration. 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III Study of desferrioxamine action by selective radioiron labels of reticuloendothelial and parenchymal cells. J Lab Clin Med 1973; 81: 876–886. 22 Trump BF, Valigorsky JM, Arstila AA, et al. The relationship of intracellular pathways of iron metabolism to cellular iron overload and iron storage diseases. Am J Pathol 1973; 72: 295–324. 23 Peters TJ, Seymour CA. Acid hydrolase activities and lysosomal integrity in liver biopsies from patients with iron overload. Clin Sci Molec Med 1976; 50: 75–78. 24 Seymour CA, Peters TJ. Organelle pathology in primary and secondary haemochromatosis with special reference to lysosomal changes. Br J Haematol 1978: 40: 239–253. 25 Beaumont C, Simon M, Smith PM, et al. Hepatic and serum ferritin concentrations in patients with idiopathic hemochromatosis. Gastroenterology 1980; 79: 877–883. 26 Selden C, Owen M, Hopkins JMP, et al. Studies on the concentration and intracellular localization of iron proteins in liver biopsy specimens from patients with iron overload with special reference to their role in lysosomal disruption. Br J Haematol 1980; 44: 593–603. 27 O'Connell M, Ward RJ, Baum H, et al. Role of iron in ferritin and haemosiderin-mediated lipid peroxidation in liposomes. Biochem J 1985; 229: 135–139. 28 Golberg L, Marti LE, Batchelor A. Biochemical changes in the tissues of animals injected with iron: 3. Lipid peroxidation. Biochem J 1962; 83: 291–298. 29 Wills ED. Effects of iron overload on lipid peroxide formation and oxidative demethylation of the liver endoplasmic reticulum. Biochem Pharmacol 1972; 21: 239–247. 30 Bacon BR, Park CH, Brittenham GM, et al. Hepatic mitochondrial oxidative metabolism in rats with chronic dietary iron overload. Hepatology 1985; 5: 789–797. 31 Bacon BR, Healey JF, Brittenham GM, et al. Hepatic microsomal function in rats with chronic dietary iron overload. Gastroenterology 1986 (in press). 32 Jacobs A. Low molecular weight intracellular iron transport compounds. Blood 1977; 50: 433–439. 33 Grohlich D, Morley CGD, Bezkorovainy A. Some aspects of iron uptake by rat hepatocytes in suspension. Int J Biochem 1979; 10: 797–802. 34 Morley CGD, Rewers KA, Bezkorovainy A. Iron metabolism pathways in the rat hepatocyte. Clin Physiol Biochem 1983; 1: 3–11. 35 Bacon BR, Tavill AS. The role of the liver in normal iron metabolism. Semin Liver Dis 1984; 4: 181–192. 36 Halliwell B, Gutteridge JMC. Oxygen toxicity, oxygen radicals, transition metals and disease. Biochem J 1984; 219: 1–14. 37 Starke PE, Farber JL. Ferric iron and superoxide ions are required for the killing of cultured hepatocytes by hydrogen peroxide. Evidence for the participation of hydroxyl radicals formed by an ironcatalyzed Haber-Weiss reaction. J Biol Chem 1985; 260: 10099–10104. 38 Thomas CE, Morehouse LA, Aust SD. Ferritin and superoxide-dependent lipid peroxidation. J Biol Chem 1985; 260: 3275–3280. 39 Pederson TC, Aust SD. The mechanism of liver microsomal lipid peroxidation. Biochim Biophys Acta 1975; 385: 232–241. 40 Kornbrust DJ, Mavis RD. Microsomal lipid peroxidation. I. Characterization of the role of iron and NADPH. Molec Pharmacol 1980; 17: 400–407. 41 Mak IT, Weglicki WB. Characterization of iron mediated peroxidative injury in isolated hepatic lysosomes. J Clin Invest 1985; 75: 58–63. 42 Bacon BR, Tavill AS, Recknagel RO. Lipid peroxidation and experimental iron overload. In: H Zimmerman, ed. Proceedings of International Symposium on Hepatotoxicity, Rouen, France, 1986 (in press). 43 Powell LW, Bassett ML, Halliday JW. Hemochromatosis: 1980 update. Gastroenterology 1980; 78: 374–381. 44 Brissot P, Bourel M, Henry D, et al. Assessment of liver iron content in 271 patients; a re-evaluation of direct and indirect methods. Gastroenterology 1981; 80: 557–565. 45 Chapman RW, Morgan MY, Laulicht M, et al. Hepatic iron stores and markers of iron overload in alcoholics and patients with idiopathic hemochromatosis. Dig Dis Sci 1982; 27: 909–916. 46 LeSage GD, Baldus WP, Fairbanks VF, et al. Hemochromatosis: genetic or alcohol-induced? Gastroenterology 1983; 84: 1471–1477. 47 Simon M, Bourel M, Genetet B, et al. Idiopathic hemochromatosis and iron overload in alcoholic liver disease: differentiation by HLA phenotype. Gastroenterology 1977; 73: 655–658. 48 Gollan JL. Diagnosis of hemochromatosis (editorial). Gastroenterology 1983; 84: 418–431. 49 Brittenham GM, Danish EH, Harris JW. Assessment of bone marrow and body iron stores: old techniques and new technologies. Semin Hematol 1981; 18: 194–221. Citing Literature Volume6, Issue1January/February 1986Pages 142-145 ReferencesRelatedInformation

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