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The utility of protein and mRNA correlation

2014; Elsevier BV; Volume: 40; Issue: 1 Linguagem: Inglês

10.1016/j.tibs.2014.10.010

1362-4326

Samuel Payne,

Molecular Biology Techniques and Applications

Transcriptomic, proteomic, and metabolomic measurements are revolutionizing the way we model and predict cellular behavior, and multi-omic comparisons are being published with increased regularity. Some have expected a trivial and predictable correlation between mRNA and protein; however, the manifest complexity of biological regulation suggests a more nuanced relationship. Indeed, observing this lack of strict correlation provides clues for new research topics, and has the potential for transformative biological insight.