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Pharmacological nature of adrenergic innervation in rat aorta

1973; Elsevier BV; Volume: 4; Issue: 14 Linguagem: Inglês

10.1016/0010-4035(73)90031-1

1878-2388

Masato Kuchii, Shoji Shibata, Jo Mori,

Veterinary Pharmacology and Anesthesia

1. No evidence for specific catecholamine fluorescence was found in any tissue layer of rat thoracic aorta, even after combined treatment with iproniazid and L-DOPA. 2. In contrast to the atria and abdominal aorta, reserpine (4 mg. per kg.) or 6-hydroxydopamine (50 mg. per kg.) did not affect the catecholamine content of the thoracic aorta. 3. Cocaine (10−5M) or desipramine (10−6M) exerted a similar differential inhibition on [3H]noradrenaline uptake by aortic tissues. 4. After pretreatment with cocaine (10−5M) or 6-hydroxydopamine (50 mg. per kg.) the dose-response curve for noradrenaline was not altered in the rat thoracic aorta. Moreover, this preparation was not highly reactive to nicotine (10−4M), tyramine (10−4M), or transmural stimulation. 5. These results suggest poor adrenergic innervation of rat thoracic aorta.