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Quantitative Struktur-Aktivitäts-Beziehungen für die Hemmung des autotrophen Wachstums synchroner Chlorella-vulgaris-Kulturen durch substituierte Thioharnstoffe

1985; Elsevier BV; Volume: 180; Issue: 5 Linguagem: Inglês

10.1016/s0015-3796(85)80087-1

0015-3796

Thomas Schelekz, Claus‐Rüdiger Kramer,

Diatoms and Algae Research

In continuation of previously described works 16 mono- and disubstituted thioureas were synthesized by known methods and tested for growth-inhibiting activity against autotrophically cultivated Chlorella vulgaris suspensions. Isoactive inhibitory values pc501) were determined from dosage-effectivity relations and used as activity parameters for structure-activity correlations. Simple and multiple regression equations are reported, discussed and compared with analogous QSAR of earlier tested series of related compounds (1-aryl-ureas, 1-aryl-thionreas, 1-aryl-2-methylisothioureas). Based on the assembly of all experimental results a linear expression between activity data pc50 and hydrophobic molecule parameters is proposed.