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The effect of vitamin B12 on some aspects of glycine metabolism

1955; Elsevier BV; Volume: 55; Issue: 1 Linguagem: Inglês

10.1016/0003-9861(55)90552-x

1096-0384

Irene J. Chang, B. Connor Johnson,

Biochemical effects in animals

The effect of vitamin B12 deficiency on the conversion of α-C14-labeled glycine to serine and choline was studied in baby pigs fed an α-protein vitamin B12-deficient synthetic milk ration containing 2.2% glycine, 0.8% methionine, and 0.1% aminoethanol. Glycine-α-C14 was shown to be a precursor of serine and of both the aminoethanol and the methyl moieties of the choline molecule in the pig as in the rat. The addition of vitamin B12 to the diet caused a fivefold increase in incorporation of the α-carbon of glycine into the methyl group of choline, while vitamin B12 nutriture had no effect on the incorporation of the α-carbon of glycine into serine and aminoethanol.