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Colon-targeted quercetin delivery using natural polymer to enhance its bioavailability

2011; Medknow; Volume: 3; Issue: 1 Linguagem: Inglês

10.4103/0974-8490.79113

0976-4836

Anil Kumar Singhal, Harsha Jain, Vipin Singhal, EdwinJ Elias, Ahmad Showkat,

Phytochemicals and Antioxidant Activities

Pharmacognosy Research,2011,3,1,35-39.DOI:10.4103/0974-8490.79113Published:April 2011Type:Original ArticleAuthors:Anil Singhal, Jain H, Vipin Singhal, Edwin J. Elias, and Ahmad Showkat Author(s) affiliations:Anil Singhal1, H Jain1, Vipin Singhal2, Edwin J Elias3, Ahmad Showkat3 1B. R. Nahata College of Pharmacy, BRNSS-Contract Research Center, Mhow-Neemuch Road, Mandsaur, Madhya Pradesh, INDIA 2Seth G L Bihani College of Technical Education, Sri Ganganagar, INDIA 3Unijules Life Science Ltd. and Associated Companies, Nagpur, INDIA Abstract:The aim of the present study is to develop a polymer (Guar Gum)-based matrix tablet (using quercetin as a model drug) with sufficient mechanical strength, and promising in vitro mouth-to-colon release profile. By definition, an oral colonic delivery system should retard drug release in the stomach and small intestine, and allow complete release in the colon. By drug delivery to the colon would therefore ensure direct treatment at the disease site, lower dosing, and fewer systemic side effects. Quercetin is antioxidant in nature and used to treat colon cancer, but they have poor absorption in the upper part of the gastrointestinal tract (GIT). As a site for drug delivery, the colon offers a near neutral pH, reduced digestive enzymatic activity, a long transit time, and an increased responsiveness to absorption enhancers. By achieving a colon-targeted drug delivery system, the absorption of quercetin may be increased, which leads to better bioactivity in fewer doses. Keywords:Antioxidant, Colon cancer, Guar gum, QuercetinView:PDF (863.76 KB)