In vitro release kinetics of biologically active transforming growth factor-β1 from a novel porous glass carrier
1997; Elsevier BV; Volume: 18; Issue: 12 Linguagem: Inglês
10.1016/s0142-9612(97)00008-2
ISSN1878-5905
AutoresSteven B. Nicoll, S. Radin, Eric M. Santos, R.S. Tuan, Paul Ducheyne,
Tópico(s)Collagen: Extraction and Characterization
ResumoSol-gel silica-based porous glass (xerogel) was used as a novel carrier material for recombinant human transforming growth factor-β1 (TGF-β1). Room temperature synthesis procedures included sol preparation, the addition of TGF-β1 solution to the sol, subsequent gelation and drying. After determination of optimal synthesis parameters, the material was assayed in vitro for its ability to release biologically active TGF-β1 in a controlled manner. Sustained release of TGF-β1 over a 7-day period was demonstrated. On the basis of published TGF-β1 potency, the amount released is capable of eliciting bone tissue reactivity. These findings suggest that this novel glass-growth factor composite may serve as an effective bone graft material for the repair of osseous defects.
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