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In vivo release of enkephalin from the globus pallidus

1981; Elsevier BV; Volume: 24; Issue: 1 Linguagem: Inglês

10.1016/0304-3940(81)90360-8

1872-7972

Alejandro Bayón, William J. Shoemaker, Lourdes Lugo, Raana Azad, Nicholas Ling, René Drucker-Colı́n, Floyd E. Bloom,

Chemical Synthesis and Analysis

Push—pull cannulae were acutely positioned through previously implanted guides in the globus pallidus of unanesthetized freely moving cats and rats. During slow-flow perfusions, enkephalin release was detected in resting conditions and increased more than 3-fold when both 50 mM K+ and 1.8 mM Ca2+ were present in the perfusing medium. Local perfusion with veratrine also enhanced enkephalin release. Furthermore, in vivo, electrical stimulation of the rat caudo-putamen enhanced enkephalin release in the pallidum. This latter finding is consistent with a functional strio-pallidal enkephalin-containing pathway previously postulated by immunohistochemical or lesion experiments.