Produção Nacional
Revisado por pares
Parasite Genotypically Related to a Monoxenous Trypanosomatid of Dog's Flea Causing Opportunistic Infection in an HIV Positive Patient
1998; Instituto Oswaldo Cruz, Ministério da Saúde; Volume: 93; Issue: 4 Linguagem: Inglês
10.1590/s0074-02761998000400021
ISSN1678-8060
AutoresRaquel S Pacheco, Mauro CA Marzochi, M.Q. Pires, Célia MM Brito, Maria de Fátima Madeira, Elizabeth G. O. Barbosa-Santos,
Tópico(s)Dermatological diseases and infestations
ResumoAn HIV positive patient presenting a clinical picture of visceral leishmaniasis co-infection was submitted to a bone marrow aspiration after admission to hospital. Amastigotes forms were seen in the bone marrow aspirate and the parasite grew in culture as promastigotes. Molecular analyses showed that the flagellates isolated did not belong to the genera Leishmania, Trypanosoma or Sauroleishmania. It was not possible to establish infection in laboratory animals. In vitro culture of mouse peritoneal macrophages revealed the invasion of the host cells by the flagellates and their killing 48 hr after infection. Opportunistic infection with an insect trypanosomatid was suspected. Further hybridization analyses against a pannel of different monoxenous and heteroxenous trypanosomatids showed kDNA cross-homology with Leptomonas pulexsimulantis a trypanosomatid found in the dog's flea
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