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Enantioselective phenylation of prochiral aldehydes using a kinetically formed chiral complex between Grignard–zinc halide reagent and N,N-dibutylnorephedrine

1991; Issue: 6 Linguagem: Inglês

10.1039/p19910001613

2050-8255

Kenso Soai, Yasuhiro Kawase, Atsushi Oshio,

Analytical Chemistry and Chromatography

Optically active phenylmethanols have been synthesized in good to high enantiomeric excess (up to 82% e.e.) by the enantioselective addition of a kinetically formed complex (between phenyl Grignard–zinc halide and N,N-dibutylnorephedrine) to aliphatic, aromatic and α,β-unsaturated aldehydes.