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Toxogonin: Blood Levels and Side Effects After Intramuscular Administration In Man

1970; Elsevier BV; Volume: 59; Issue: 6 Linguagem: Inglês

10.1002/jps.2600590615

1520-6017

Frederick R. Sidell, William A. Groff,

Organic Chemistry Synthesis Methods

Toxogonin, given intramuscularly to 10 healthy young men in doses of 2.5–10 mg./kg., produced dose-related oxime whole blood levels of 6.3–26.5 mcg./ml. and had a plasma half-time of 82.8 min. Associated side effects included tachycardia, hypertension, and a dose-independent symptom complex consisting of peroral warmth, paresthesia and hypalgesia, and a menthol taste. Some published data on the relative effectiveness of toxogonin and pralidoxime (chloride and methanesulfonate) suggest further inquiry into toxogonin's therapeutic potential may be needed.