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BIBTEX RIS

Influence of Melanosome Dynamics on Melanoma Drug Sensitivity

2009; Oxford University Press; Volume: 101; Issue: 18 Linguagem: Inglês

10.1093/jnci/djp259

ISSN

1460-2105

Autores

Kevin G. Chen, Richard D. Leapman, Guofeng Zhang, Barry Lai, Julio C. Valencia, Carol Cardarelli, Wilfred D. Vieira, Vincent J. Hearing, Michael M. Gottesman,

Tópico(s)

RNA Interference and Gene Delivery

Resumo

BackgroundMalignant melanomas are intrinsically resistant to many conventional treatments, such as radiation and chemotherapy, for reasons that are poorly understood. Here we propose and test a model that explains drug resistance or sensitivity in terms of melanosome dynamics.

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