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Untersuchungen in der Chinuclidin‐Reihe. 2. Mitteilung. 4‐Chinuclidin‐carbonsäure

1954; Wiley; Volume: 37; Issue: 6 Linguagem: Inglês

10.1002/hlca.19540370611

1522-2675

C. A. Grob, E. Renk,

Synthesis and Catalytic Reactions

Abstract Consecutive C‐ and N‐alkylation of 1‐methyl‐4‐cyano‐piperidine (I) with 1,2‐dichloro‐ethane affords 1‐methyl‐4‐cyano‐quinuclidinium chloride (III). Upon heating this salt is converted into 4‐cyanoquinuclidine (IV), from which 4‐quinuclidine‐carboxylic acid is obtained after hydrolysis.