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Enhancement after feline immunodeficiency virus vaccination

1992; Elsevier BV; Volume: 35; Issue: 1-2 Linguagem: Inglês

10.1016/0165-2427(92)90131-9

1873-2534

Margaret J. Hosie, Robert Osborne, George Reid, James C. Neil, Oswald Jarrett,

Herpesvirus Infections and Treatments

ADV is a non-defective parvovirus (single stranded DNA virus), which causes a persistent infection in mink and a slowly progressive lymphoproliferative disease, characterised by plasmacytosis, hypergammaglobulinaemia and immune complex-mediated glomerulonephritis and arteritis.Earlier vaccination efforts have failed so far, probably because the vaccines contained low amounts of inactivated virus.In one report (Porter et al., J. Immunol.72, 1, 1972) vaccination was even described to increase the severity of disease.We have produced relatively large amounts of ADV structural proteins in a recombinant baculovirus expression system and used them in various vaccines.The results of these ongoing studies will be reported.