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Effect of excess fluoride ingestion on human thyroid function in Gaya region, Bihar, India

2013; Taylor & Francis; Volume: 95; Issue: 7 Linguagem: Inglês

10.1080/02772248.2013.847619

1029-0486

Shahla Yasmin, Sumeet Ranjan, Hilaluddin, Doris H. D’Souza,

Mercury impact and mitigation studies

Fluoride (F) is mainly ingested through drinking water and food. In addition to producing dental and skeletal fluorosis, excess fluoride may affect the functioning of many organs including the thyroid gland. The present study investigated the thyroid function of subjects with dental fluorosis from F-endemic areas of Gaya region, Bihar, India and compared it with control individuals from Bodh Gaya. The mean F concentration in groundwater of F-endemic area was 2.82 ± 0.18 mg/L (range 0.62–7.2 mg/L), while that of control area was 0.49 ± 0.04 mg/L (range 0.21–0.76 mg/L). Abnormal levels of T3, T4, and TSH were found in the study subjects from both control and F-endemic areas.