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Ketene Acetal and Spiroacetal Constituents of the Marine Fungus Aigialus p arvus BCC 5311

2004; American Chemical Society; Volume: 67; Issue: 3 Linguagem: Inglês

10.1021/np030344d

1520-6025

Pornrapee Vongvilai, Masahiko Isaka, Prasat Kittakoop, Prasert Srikitikulchai, Palangpon Kongsaeree, Yodhathai Thebtaranonth,

Synthetic Organic Chemistry Methods

Aigialone (1) and aigialospirol (2), two structurally unique compounds, were isolated from the mangrove fungus Aigialus parvus BCC 5311. The structure of the new ketene acetal 1 was elucidated by spectral analysis, and its relative stereochemistry was determined by X-ray crystallography. The stereochemistry of aigialospirol (2), elucidated by NMR spectral analysis, suggested that this compound is possibly derived from hypothemycin (3), a metabolite previously isolated from this same fungus.