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Drug‐Induced Hypersensitivity Syndrome Due to Anticonvulsants in a Two‐Year‐Old Boy

2004; Wiley; Volume: 31; Issue: 12 Linguagem: Inglês

10.1111/j.1346-8138.2004.tb00645.x

1346-8138

Paulo Ricardo Criado, Roberta Fachini Jardim Criado, Cí­dia Vasconcellos, José Roberto Pereira Pegas, Patrícia Calil,

Immunodeficiency and Autoimmune Disorders

Abstract Drug‐induced hypersensitivity syndrome (DIHS) usually refers to severe cutaneous drug eruption associated with systemic involvement and potentially fatal outcome. We report a 2‐year‐old Caucasian boy who developed DIHS due to phenytoin and phenobarbital and who showed extensive internal organ involvement. We are alerting that failure to recognize this drug eruption and discontinue the culprit drug may result in increased severity, greater extent of internal organ involvement, and fatal outcome. The recent research about the influence of human herpesvirus 6 co‐infection on the pathogenesis of DIHS is also discussed by the authors in this paper.