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HIV-DNA in rectal cells is well correlated with HIV-DNA in blood in different groups of patients, including long-term non-progressors

2008; Lippincott Williams & Wilkins; Volume: 22; Issue: 14 Linguagem: Inglês

10.1097/qad.0b013e32830fbdbc

1473-5571

Véronique Avettand-Fènoël, Thiérry Prazuck, Laurent Hocqueloux, Adeline Mélard, Christophe Michau, R. Kerdraon, Eric Agoute, Christine Rouzioux,

HIV-related health complications and treatments

Most of the body's lymphoid tissue is in gut and constitutes an immense HIV reservoir. We quantified HIV-DNA in rectum and compared it with blood levels for 27 HIV-infected adults from different groups. We observed a large range of rectal and blood HIV-DNA levels. They were positively correlated (r = 0.841, P<0.0001). Long-term nonprogressors and patients in 'remission' after antiretroviral treatment interruption had the lowest blood and mucosal HIV-DNA levels.