Portal de Periódicos da CAPES

How Lymphocytes Kill Tumor Cells

1976; Massachusetts Medical Society; Volume: 295; Issue: 3 Linguagem: Inglês

10.1056/nejm197607152950311

1533-4406

A. C. Allison, J. Ferluga,

T-cell and B-cell Immunology

During the past decade evidence has accumulated that many tumors in man and in laboratory animals stimulate immune responses. These responses are complex, involving antibody formation, T-lymphocyte-mediated tumor-cell cytotoxicity, antibody-dependent killing by nonspecific effector cells (K cells) and activated macrophages. To use immunotherapy in clinical oncology, it is necessary to understand the mechanisms by which immune responses result in killing of tumor cells and how the effectiveness of these mechanisms can be increased. Most information has been accumulated about T lymphocytes in well defined experimental situations.The systematic studies of Brunner1 and Cerottini2 and their colleagues showed that thymus-derived T . . .