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Moderate hyperprolactinemia is associated with survival in patients with acute graft-versus-host disease after allogeneic stem cell transplantation

2012; Maney Publishing; Volume: 17; Issue: 2 Linguagem: Inglês

10.1179/102453312x13221316477930

1607-8454

Adalberto Parra, Jorge Ramírez‐Peredo, Enrique Reyes-Muñoz, Rocío Hidalgo, Julio Macías-Gallardo, Julia Lutz‐Presno, Alejandro Ruı́z-Argüelles, Eduardo Arias de la Garza, Eduardo Infante, César Homero Gutiérrez‐Aguirre, Rosario Salazar‐Riojas, Jesús Z. Villarreal, David Gómez‐Almaguer, Guillermo J. Ruíz‐Argüelles,

Immune Cell Function and Interaction

Fasting serum prolactin (PRL) levels in response to metoclopramide (MCP) and lymphocyte cytokine profiles was studied in patients given allografts and their donors. Thirty normoprolactinemic volunteers (12-59 years) were studied: group 1, 10 healthy men; group 2, 8 males and 2 females with various hematologic diseases; and group 3, 3 males and 7 females HLA-identical sibling donors: PRL and cytokines were measured. Four surviving recipients developed acute graft-versus-host disease (GVHD) (+), and six did not. Before transplant Fasting PRL concentrations were higher in 'future' GVHD(+) recipients than in their donors (P < 0.001). The opposite was seen in response to MCP (P = 0.01). Donors had a predominant T-helper type 1 (Th1) cytokine profile compared with recipients (P ≤ 0.02), and GVHD(+) recipients had a greater tumor necrosis factor (TNF) value than GVHD(-) (P = 0.05). After transplant On days +30 and +100, a mild sustained rise in fasting PRL levels occurred only in GVHD(+) recipients (P ≤ 0.05) simultaneously with a transient rise in Th1 cytokines. GVHD(-) recipients had no changes. Donors with a Th1 cytokine profile might be more prone to induce GVHD in their recipients, and a mild sustained rise in PRL concentrations after transplantation in recipients GVHD(+) might participate in the amelioration of the severity of GVHD.